1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester

Name	FK-448 Free base
Synonyms	FK-448 Free base 1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester
CAS	85858-76-0

Molecular Formula	C25H30N2O3
Molar Mass	406.52
Storage Condition	2-8℃
Use	FK-448 Free base is a potent, specific chymotrypsin inhibitor with an IC50 value of 720 nM.
In vitro study	FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC 50 of 720 nM. FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC 50 s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC 50 s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC 50 of 15 μM.
In vivo study	FK-448 (20 mg/kg, i.p.) results in a decrease in the blood glucose level, and inhibits the degradation of insulin by pancreatic enzymes in rats. FK-448 (20 mg/kg, p.o.) also decreases the blood glucose level, and increases plasma IRI level in dogs.

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